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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically characterized by a focus on practical aspects of the research design, like the recruitment and consent process as well as adherence to the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. However excessive heterogeneity could lead to problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to assess the causal relationship between an intervention and its effects. However, they shouldn't be used as a substitute for explanatory studies.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, 프라그마틱 정품 which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool attempted to define the features of a practical trial which includes the recruitment process, 프라그마틱 사이트 the design and delivery of the intervention, and monitoring.

There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary-care settings.