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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of design which include the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographical regions. This type of heterogeneity that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. However too much heterogeneity could lead to problems with the design of the trial.

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Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. Its software is accessible on mobile devices and in multiple languages. It has established itself as one of the leading gaming platforms in the casino industry despite its relative infancy. The latest releases include Wolves which is a five-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by practitioners and policy makers to inform their decision making. They are also a good method to determine the causality between the intervention and its effects. They should, however, not, be used to replace explanation studies.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, 프라그마틱 정품확인방법 which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, and monitoring.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.